Autoantibody Screening, Autoantigen Arrays

Autoantibody screening is a powerful tool for screening samples to ascertain correlations between autoantibodies and disease.  These tools can be used in diagnosis, monitoring of a disease or medication efficacy, and understanding the biological pathways involved. Common applications include the detection of novel autoantibodies in any diseases, as well as identifying novel tumor-associated antigens in cancer or other diseases. 4 different quantitative platforms are offered.

  • Most popular 128-plex Autoantigen Array with 128 known autoantigensEach slide allows the processing of 15 samples and a PBS control. This assay is ideal for screening serum or plasma samples for known or novel autoantibodies, of any immunoglobulin class. Other body fluids can also be interrogated. See platform detail here.
  • The Human Proteome Microarray V4.0 from CDI laboratories bears targets covering >21,000 human proteins. Representing the largest such proteome array available, this platform is suitable for large screening projects where the goal is to comprehensively screen the human proteome to identify targets for antibodies, aptamers, or other ligands. See platform details here.
  • Immunone™ v4 from Sengenics expresses 1631 fully folded functional proteins from biologically significant protein families including kinases, signaling molecules, cytokines, interleukins, chemokines, and cancer antigens. Since all proteins on these arrays are fully folded, conformational epitopes are preserved. This platform is also suitable for screening projects where the goal is to screen the functional human proteome to identify targets for antibodies, aptamers, or other ligands. See platform details here.
  • Smaller custom panels, including this one developed by Millipore Sigma for the Luminex platform. These smaller panels offer an affordable option to monitor the autoimmune response to a focused set of targets. Other custom panels can also be generated and processed.